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Cell>Point, L.L.C. Executes
Exclusive Worldwide Patent and Technology
License Agreement for ethylenedicysteine —
7|1|01
HOUSTON, Texas - July 2001 - Cell>Point, L.L.C.
executed an exclusive worldwide Patent and
Technology License Agreement with The University
of Texas M.D. Anderson Cancer Center for
ethylenedicysteine ("EC") drug conjugate
technology which functions as a chemical bridge
linking diagnostic radio-tracers or therapeutic
radionuclides to ligand disease target seekers
or novel FDA approved drugs.
Technetium-99m-EC-deoxyglucose ("99mTc-EC-DG")
will be the first of many compounds to emerge
from the EC technology portfolio. The Phase I
clinical trial for 99mTc-EC-DG will be conducted
at M.D. Anderson. 99mTc-EC-DG produces a
metabolic imaging marker that can diagnose
hyper-cellular activity of cancer cells using
standard Single Photon Emission Computed
Tomography (SPECT). The use of 99mTc in most of
the EC Technology applications will yield
certain advantages over other radioisotopes.
99mTc is widely available, very inexpensive
compared to most other Radioisotopes and has a
six hour half-life. This will make 99mTc-EC-DG
ideal for sequential time phased imaging. The
company believes that the development of
99mTc-EC-DG will provide certain credibility for
the technology platform and help demonstrate the
downstream potential for EC technology.

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